Inflammatory myofibroblastic tumours of the respiratory tract: paediatric case series with varying clinical presentations

J Laryngol Otol. 2011 Aug;125(8):865-8. doi: 10.1017/S0022215111000648. Epub 2011 Apr 12.


Objectives: To highlight the clinical importance of inflammatory myofibroblastic tumours of the respiratory tract in children, and to present a case series of three children which illustrates this tumour's variable clinical presentation.

Case history: The series includes: a nine-year-old girl with a diagnosis of juvenile idiopathic arthritis, who presented with finger clubbing and was found to have an inflammatory myofibroblastic tumour in her right upper lobe; a 15-year-old adolescent with a left main stem bronchial inflammatory myofibroblastic tumour, who presented with breathlessness and chest pain; and a 12-year-old girl with a tracheal inflammatory myofibroblastic tumour who presented with stridor. In each case, the tumour was resected surgically.

Conclusion: Inflammatory myofibroblastic tumour are a rare but clinically important and pathologically distinct lesion of the respiratory tract in children. The cases in this series highlight some of the varied clinical presentations of inflammatory myofibroblastic tumours, and illustrate some of this tumour's different anatomical locations within the paediatric respiratory tract.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Anaplastic Lymphoma Kinase
  • Antirheumatic Agents / therapeutic use
  • Arthralgia / etiology
  • Arthritis, Juvenile / diagnosis
  • Bronchoscopy
  • Child
  • Dyspnea / etiology
  • Female
  • Granuloma, Plasma Cell / diagnosis
  • Granuloma, Plasma Cell / metabolism
  • Granuloma, Plasma Cell / surgery
  • Histiocytoma, Benign Fibrous / diagnosis
  • Histiocytoma, Benign Fibrous / surgery
  • Humans
  • Lung Neoplasms / diagnosis*
  • Lung Neoplasms / metabolism
  • Lung Neoplasms / surgery
  • Methotrexate / therapeutic use
  • Neoplasms, Muscle Tissue / diagnosis*
  • Neoplasms, Muscle Tissue / metabolism
  • Neoplasms, Muscle Tissue / surgery
  • Osteoarthropathy, Secondary Hypertrophic / etiology
  • Receptor Protein-Tyrosine Kinases / metabolism
  • Recurrence
  • Respiratory Sounds / etiology
  • Respiratory Tract Diseases / diagnostic imaging
  • Respiratory Tract Diseases / metabolism
  • Respiratory Tract Diseases / surgery*
  • Skin Neoplasms / surgery
  • Staining and Labeling
  • Thigh / pathology
  • Tomography, X-Ray Computed


  • Antirheumatic Agents
  • Anaplastic Lymphoma Kinase
  • Receptor Protein-Tyrosine Kinases
  • Methotrexate