From virus to inflammation: mechanisms of RIG-I-induced IL-1β production

Eur J Cell Biol. 2012 Jan;91(1):59-64. doi: 10.1016/j.ejcb.2011.01.013. Epub 2011 Apr 9.

Abstract

Early detection of viruses by the innate immune system is critical for host defense. Antiviral immunity is initiated by germline encoded pattern recognition receptors (PRRs) that recognize viral pathogen-associated molecular patterns (PAMPs) such as nucleic acids. Intracellular PRRs then drive the production of interferons and cytokines to orchestrate immune responses. One key host factor that is critical for antiviral immunity and for systemic inflammatory reactions including fever is interleukin-1beta (IL-1β). Here we discuss current insights into the molecular mechanisms how the cytosolic RNA helicase RIG-I triggers NF-κB signaling and inflammasome activation specifically for RNA virus-induced IL-1β production.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / immunology
  • Adaptor Proteins, Signal Transducing / metabolism
  • Animals
  • CARD Signaling Adaptor Proteins
  • Carrier Proteins / immunology
  • Carrier Proteins / metabolism
  • Caspase 1 / immunology
  • Caspase 1 / metabolism
  • Host-Pathogen Interactions
  • Humans
  • Immunity, Innate*
  • Inflammasomes / immunology
  • Inflammasomes / metabolism
  • Inflammation / immunology*
  • Inflammation / metabolism
  • Inflammation / virology
  • Interferons / biosynthesis
  • Interferons / immunology
  • Interleukin-1beta / biosynthesis
  • Interleukin-1beta / immunology
  • Membrane Proteins / genetics
  • Membrane Proteins / immunology
  • Membrane Proteins / metabolism*
  • Mice
  • NF-kappa B / immunology
  • NF-kappa B / metabolism
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / immunology
  • Nerve Tissue Proteins / metabolism*
  • RNA Viruses / immunology*
  • RNA Viruses / metabolism
  • Receptors, Cell Surface
  • Receptors, Pattern Recognition / immunology
  • Receptors, Pattern Recognition / metabolism*
  • Signal Transduction / genetics
  • Signal Transduction / immunology*
  • Virus Diseases / immunology*
  • Virus Diseases / metabolism
  • Virus Diseases / virology
  • Virus Internalization

Substances

  • Adaptor Proteins, Signal Transducing
  • CARD Signaling Adaptor Proteins
  • Card9 protein, mouse
  • Carrier Proteins
  • Inflammasomes
  • Interleukin-1beta
  • Membrane Proteins
  • NF-kappa B
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Nerve Tissue Proteins
  • Nlrp3 protein, mouse
  • Receptors, Cell Surface
  • Receptors, Pattern Recognition
  • Robo3 protein, mouse
  • Interferons
  • Caspase 1