No association between the PCM1 gene and schizophrenia: a multi-center case-control study and a meta-analysis

Schizophr Res. 2011 Jun;129(1):80-4. doi: 10.1016/j.schres.2011.03.024. Epub 2011 Apr 9.

Abstract

Alterations in centrosomal function have been suggested in the pathology of schizophrenia. The molecule pericentriolar material 1 (PCM1) is involved in maintaining centrosome integrity and in the regulation of the microtubule cytoskeleton. PCM1 forms a complex at the centrosome with the disrupted-in-schizophrenia 1 (DISC1) protein, which is a major susceptibility factor for schizophrenia. The association between genetic variants in the PCM1 gene and schizophrenia has been reported by several case-control studies, linkage studies and a meta-analysis. The aims of this study are to replicate the association between four single-nucleotide polymorphisms (SNPs) in the PCM1 gene and schizophrenia in a Japanese population (1496 cases and 1845 controls) and to perform a meta-analysis of the combined sample groups (3289 cases and 3567 controls). We failed to find a significant association between SNPs or haplotypes of the PCM1 gene and schizophrenia in the Japanese population (P>0.28). The meta-analysis did not reveal an association between the four examined SNPs and schizophrenia. Our data did not support genetic variants in the PCM1 gene as a susceptibility locus for schizophrenia.

Publication types

  • Meta-Analysis
  • Multicenter Study

MeSH terms

  • Adult
  • Asians / genetics*
  • Autoantigens / genetics*
  • Case-Control Studies
  • Cell Cycle Proteins / genetics*
  • Female
  • Genetic Predisposition to Disease
  • Haplotypes
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Schizophrenia / genetics*

Substances

  • Autoantigens
  • Cell Cycle Proteins
  • PCM1 protein, human