Boronated unnatural cyclic amino acids as potential delivery agents for neutron capture therapy

George W Kabalka; Aarif L Shaikh; Rolf F Barth; Tianyao Huo; Weilian Yang; Pamela M Gordnier; Subhash Chandra

doi:10.1016/j.apradiso.2011.03.035

Boronated unnatural cyclic amino acids as potential delivery agents for neutron capture therapy

Appl Radiat Isot. 2011 Dec;69(12):1778-81. doi: 10.1016/j.apradiso.2011.03.035. Epub 2011 Mar 31.

Authors

George W Kabalka¹, Aarif L Shaikh, Rolf F Barth, Tianyao Huo, Weilian Yang, Pamela M Gordnier, Subhash Chandra

Affiliation

¹ Departments of Radiology and Chemistry, The University of Tennessee, Knoxville, TN, USA.

Abstract

Boron delivery characteristics of cis and trans isomers of a boronated unnatural amino acid, 1-amino-3-boronocyclopentanecarboxylic acid (ABCPC) were tested in the B16 mouse model for human melanoma. Both ABCPC isomers delivered comparable boron to B16 melanoma tumor cells as L-p-boronophenylalanine (BPA). Secondary ion mass spectrometry (SIMS) analysis revealed the presence of boron throughout the tumor from these compounds, and a near homogeneous distribution between the nucleus and cytoplasm of B16 cells grown in vitro. These encouraging observations support further studies of these new boron carriers in BNCT.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Amino Acids, Cyclic / chemistry*
Animals
Boron / chemistry*
Boron Neutron Capture Therapy*
Female
Melanoma, Experimental / radiotherapy*
Mice
Mice, Inbred BALB C
Spectrometry, Mass, Secondary Ion

Substances

Amino Acids, Cyclic
Boron

Abstract

Publication types

MeSH terms

Substances

Grants and funding