Genomic imprinting: an obsession with depilatory mice

Curr Biol. 2011 Apr 12;21(7):R257-9. doi: 10.1016/j.cub.2011.02.027.


Excessive grooming in mice has been promoted as a model of human obsessive-compulsive disorders. A recent paper adds Grb10 to the list of genes with effects on behavioral hair loss, with the added twist that this time the gene is imprinted.

MeSH terms

  • Animals
  • Disease Models, Animal
  • GRB10 Adaptor Protein / genetics
  • Genomic Imprinting*
  • Grooming*
  • Humans
  • Mice
  • Obsessive-Compulsive Disorder / genetics*


  • GRB10 Adaptor Protein