Chemokines and cancer: a fatal attraction

Cancer Cell. 2011 Apr 12;19(4):434-5. doi: 10.1016/j.ccr.2011.03.017.


Chemokines are important components of cancer-related inflammation. In this issue of Cancer Cell, Chen et al. report that the chemokine CCL18, produced by tumor-associated macrophages, promotes malignant behavior and correlates with metastasis in human breast cancer. Unexpectedly, PITPNM3/Nir1, a molecule unrelated to chemokine receptors, was identified as its elusive receptor.

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