ROS signaling: the new wave?

Trends Plant Sci. 2011 Jun;16(6):300-9. doi: 10.1016/j.tplants.2011.03.007. Epub 2011 Apr 7.


Reactive oxygen species (ROS) play a multitude of signaling roles in different organisms from bacteria to mammalian cells. They were initially thought to be toxic byproducts of aerobic metabolism, but have now been acknowledged as central players in the complex signaling network of cells. In this review, we will attempt to address several key questions related to the use of ROS as signaling molecules in cells, including the dynamics and specificity of ROS signaling, networking of ROS with other signaling pathways, ROS signaling within and across different cells, ROS waves and the evolution of the ROS gene network.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Evolution, Molecular
  • Hydrogen Peroxide / metabolism
  • Indoleacetic Acids / metabolism
  • NADPH Oxidases / metabolism
  • Oxygen / metabolism
  • Plant Growth Regulators / metabolism
  • Reactive Oxygen Species / metabolism*
  • Signal Transduction*
  • Superoxides / metabolism
  • Viridiplantae / genetics
  • Viridiplantae / metabolism*


  • Indoleacetic Acids
  • Plant Growth Regulators
  • Reactive Oxygen Species
  • Superoxides
  • Hydrogen Peroxide
  • NADPH Oxidases
  • Oxygen