Sublethal exposure to crude oil during embryonic development alters cardiac morphology and reduces aerobic capacity in adult fish

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7086-90. doi: 10.1073/pnas.1019031108. Epub 2011 Apr 11.

Abstract

Exposure to high concentrations of crude oil produces a lethal syndrome of heart failure in fish embryos. Mortality is caused by cardiotoxic polycyclic aromatic hydrocarbons (PAHs), ubiquitous components of petroleum. Here, we show that transient embryonic exposure to very low concentrations of oil causes toxicity that is sublethal, delayed, and not counteracted by the protective effects of cytochrome P450 induction. Nearly a year after embryonic oil exposure, adult zebrafish showed subtle changes in heart shape and a significant reduction in swimming performance, indicative of reduced cardiac output. These delayed physiological impacts on cardiovascular performance at later life stages provide a potential mechanism linking reduced individual survival to population-level ecosystem responses of fish species to chronic, low-level oil pollution.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cytochrome P-450 Enzyme System / biosynthesis*
  • Ecosystem*
  • Female
  • Fish Diseases* / chemically induced
  • Fish Diseases* / enzymology
  • Fish Diseases* / pathology
  • Heart Failure* / chemically induced
  • Heart Failure* / enzymology
  • Heart Failure* / pathology
  • Heart Failure* / veterinary
  • Male
  • Myocardium* / enzymology
  • Myocardium* / pathology
  • Petroleum / toxicity*
  • Polycyclic Aromatic Hydrocarbons / toxicity*
  • Water Pollutants, Chemical / toxicity*
  • Zebrafish / metabolism*
  • Zebrafish Proteins / biosynthesis

Substances

  • Petroleum
  • Polycyclic Aromatic Hydrocarbons
  • Water Pollutants, Chemical
  • Zebrafish Proteins
  • Cytochrome P-450 Enzyme System