Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster

Aging (Albany NY). 2011 Apr;3(4):391-4. doi: 10.18632/aging.100314.

Abstract

Aging is associated with NF-κB-dependent pro-inflammation. Here we demonstrated that inhibition of NF-κB with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / pharmacology
  • Drosophila melanogaster / drug effects*
  • Drosophila melanogaster / physiology*
  • Female
  • Longevity / drug effects*
  • Male
  • NF-kappa B / antagonists & inhibitors*
  • Pyrrolidines / pharmacology*
  • Thiocarbamates / pharmacology*

Substances

  • Antioxidants
  • NF-kappa B
  • Pyrrolidines
  • Thiocarbamates
  • pyrrolidine dithiocarbamic acid