Protective effect of lycopene on oxidative stress and cognitive decline in rotenone induced model of Parkinson's disease

Neurochem Res. 2011 Aug;36(8):1435-43. doi: 10.1007/s11064-011-0469-3. Epub 2011 Apr 12.


Evidence from clinical and experimental studies indicate that oxidative stress is involved in pathogenesis of Parkinson's disease. The present study was designed to investigate the neuroprotective potential of lycopene on oxidative stress and neurobehavioral abnormalities in rotenone induced PD. Rats were treated with rotenone (3 mg/kg body weight, intraperitoneally) for 30 days. NADH dehydrogenase a marker of rotenone action was observed to be significantly inhibited (35%) in striatum of treated animals. However, lycopene administration (10 mg/kg, orally) to the rotenone treated animals for 30 days increased the activity by 39% when compared to rotenone treated animals. Rotenone administration increased the MDA levels (75.15%) in striatum, whereas, lycopene administration to rotenone treated animals decreased the levels by 24.33%. Along with this, significant decrease in GSH levels (42.69%) was observed in rotenone treated animals. Lycopene supplementation on the other hand, increased the levels of GSH by 75.35% when compared with rotenone treated group. The activity of SOD was inhibited by 69% in rotenone treated animals and on lycopene supplementation; the activity increased by 12% when compared to controls. This was accompanied by cognitive and motor deficits in rotenone administered animals, which were reversed on lycopene treatment. Lycopene treatment also prevented release of cytochrome c from mitochondria. Collectively, these observations suggest that lycopene supplementation along with rotenone for 30 days prevented rotenone-induced alterations in antioxidants along with the prevention of rotenone induced oxidative stress and neurobehavioral deficits. The results provide an evidence for beneficial effect of lycopene supplementation in rotenone-induced PD and suggest therapeutic potential in neurodegenerative diseases involving accentuated oxidative stress.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase / metabolism
  • Animals
  • Antioxidants / metabolism
  • Antioxidants / pharmacology*
  • Carotenoids / pharmacology*
  • Cognition / drug effects*
  • Cytochromes c / metabolism
  • Disease Models, Animal
  • Humans
  • Lycopene
  • Male
  • NADH Dehydrogenase / metabolism
  • Neuropsychological Tests
  • Oxidative Stress / drug effects*
  • Parkinson Disease, Secondary / chemically induced*
  • Parkinson Disease, Secondary / physiopathology*
  • Random Allocation
  • Rats
  • Rats, Wistar
  • Rotenone / toxicity*
  • Uncoupling Agents / toxicity


  • Antioxidants
  • Uncoupling Agents
  • Rotenone
  • Carotenoids
  • Cytochromes c
  • NADH Dehydrogenase
  • Acetylcholinesterase
  • Lycopene