Dosimetry of yttrium-labelled radiopharmaceuticals for internal therapy: 86Y or 90Y imaging?

Eur J Nucl Med Mol Imaging. 2011 May;38 Suppl 1:S57-68. doi: 10.1007/s00259-011-1771-7. Epub 2011 Mar 11.

Abstract

This paper reviews issues concerning (86)Y positron emission tomography (PET), (90)Y PET and (90)Y bremsstrahlung imaging. Specific methods and corrections developed for quantitative imaging, for application in preclinical and clinical studies, and to assess (90)Y dosimetry are discussed. The potential imaging capabilities with the radioisotopes (87)Y and (88)Y are also considered. Additional studies required to assess specific unaddressed issues are also identified.

Publication types

  • Review

MeSH terms

  • Animals
  • Forecasting
  • Half-Life
  • Humans
  • Positron-Emission Tomography / methods*
  • Radiometry / methods*
  • Radiopharmaceuticals / administration & dosage
  • Radiopharmaceuticals / pharmacokinetics
  • Radiotherapy Planning, Computer-Assisted / methods
  • Tissue Distribution
  • Tomography, Emission-Computed / methods
  • Yttrium Radioisotopes / administration & dosage*
  • Yttrium Radioisotopes / chemistry*

Substances

  • Radiopharmaceuticals
  • Yttrium Radioisotopes