Inhibitory effect of açaí (Euterpe oleracea Mart.) pulp on IgE-mediated mast cell activation

J Agric Food Chem. 2011 May 25;59(10):5595-601. doi: 10.1021/jf2005707. Epub 2011 May 4.


The palm fruit açaí is known to have potential health benefits due to its antioxidant scavenging capacities. Pretreatment of IgE-sensitized mouse primary cultured mast cells with açaí pulp resulted in the dramatic suppression of antigen-induced degranulation in a dose-dependent manner. Similarly, açaí suppressed IgE-mediated degranulation and transcription of the cytokine genes from a cultured mast cell line of rat basophilic leukemia (RBL)-2H3 cells. Açaí could selectively inhibit FcεRI signaling pathways. Furthermore, the FcεRI-mediated complementary signaling pathway was also suppressed by açaí. These results demonstrate that açaí is a potent inhibitor of IgE-mediated mast cell activation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arecaceae*
  • Cell Degranulation
  • Cell Line, Tumor
  • Cytokines / genetics
  • Fruit*
  • Gene Expression
  • Immunoglobulin E / immunology*
  • Leukemia, Basophilic, Acute
  • Mast Cells / immunology*
  • Mast Cells / physiology
  • Rats
  • Receptors, IgE / immunology
  • Signal Transduction
  • src-Family Kinases / metabolism


  • Cytokines
  • FCER1A protein, rat
  • Receptors, IgE
  • Immunoglobulin E
  • lyn protein-tyrosine kinase
  • src-Family Kinases