Abstract
IspH is a 4Fe-4S protein that carries out an essential reduction step in isoprenoid biosynthesis. Using hyperfine sublevel correlation (HYSCORE) spectroscopy, we show that pyridine inhibitors of IspH directly bind to the unique fourth Fe in the 4Fe-4S cluster, opening up new routes to inhibitor design, of interest in the context of both anti-bacterial as well as anti-malarial drug discovery.
© 2011 American Chemical Society
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology*
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Bacteria / drug effects
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Bacteria / metabolism*
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Bacterial Proteins / metabolism*
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Drug Design
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Iron-Sulfur Proteins / metabolism*
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Models, Molecular
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Protein Binding
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Pyridines / chemistry*
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Pyridines / pharmacology*
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Terpenes / metabolism
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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Iron-Sulfur Proteins
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Pyridines
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Terpenes
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pyridine