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. 2011 May 27;74(5):1106-10.
doi: 10.1021/np2000478. Epub 2011 Apr 12.

Prenylated Polyhydroxy-p-terphenyls from Aspergillus taichungensis ZHN-7-07

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Prenylated Polyhydroxy-p-terphenyls from Aspergillus taichungensis ZHN-7-07

Shengxin Cai et al. J Nat Prod. .

Abstract

Six new prenylated polyhydroxy-p-terphenyl metabolites, named prenylterphenyllins A-C (1-3) and prenylcandidusins A-C (5-7), and one new polyhydroxy-p-terphenyl with a simple tricyclic C-18 skeleton, named 4''-dehydro-3-hydroxyterphenyllin (4), were obtained together with eight known analogues (8-15) from Aspergillus taichungensis ZHN-7-07, a root soil fungus isolated from the mangrove plant Acrostichum aureum. Their structures were determined by spectroscopic methods, and their cytotoxicity was evaluated using HL-60, A-549, and P-388 cell lines. Compounds 1 and 8 exhibited moderate activities against all three cell lines (IC50 1.53-10.90 μM), whereas compounds 4 and 6 displayed moderate activities only against the P-388 cell line (IC50 of 2.70 and 1.57 μM, respectively).

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