Heterogeneous cardiac proteasomes: mandated by diverse substrates?

Physiology (Bethesda). 2011 Apr;26(2):106-14. doi: 10.1152/physiol.00039.2010.


Proteasome biology has taken central stage in cardiac physiology and pathophysiology. The molecular heterogeneity of proteasome subpopulations supports the specificity of proteasome function to degrade diverse substrate repertoires. Unveiling the dynamics of proteasome function should inspire new therapeutic strategies for combating cardiac disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Heart / physiology*
  • Humans
  • Myocardium / chemistry
  • Myocardium / metabolism*
  • Proteasome Endopeptidase Complex / chemistry
  • Proteasome Endopeptidase Complex / metabolism*
  • Signal Transduction
  • Substrate Specificity


  • Proteasome Endopeptidase Complex