Aldosterone paradox: differential regulation of ion transport in distal nephron

Physiology (Bethesda). 2011 Apr;26(2):115-23. doi: 10.1152/physiol.00049.2010.


The mechanisms through which aldosterone promotes apparently opposite effects like salt reabsorption and K(+) secretion remain poorly understood. The identification, localization, and physiological analysis of ion transport systems in distal nephron have revealed an intricate network of interactions between several players, revealing the complex mechanism behind the aldosterone paradox. We review the mechanisms involved in differential regulation of ion transport that allow the fine tuning of salt and K(+) balance.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aldosterone / physiology*
  • Animals
  • Humans
  • Ion Transport / physiology
  • Kidney Tubules, Distal / physiology*
  • Potassium / metabolism
  • Sodium Chloride / metabolism


  • Sodium Chloride
  • Aldosterone
  • Potassium