Effects of serotonin on blood glucose and insulin levels of glucose- and streptozotocin-treated mice

Jpn J Pharmacol. 1990 Sep;54(1):93-6. doi: 10.1254/jjp.54.93.


Effects of serotonin (5-HT) on plasma glucose and serum insulin levels were studied in mice. In normal mice, 5-HT induced a dose-dependent hypoglycemia and an increase in serum insulin levels. 5-HT significantly inhibited glucose-induced hyperglycemia and increased glucose-stimulated insulin release. However, in streptozotocin-induced diabetic mice, 5-HT changed neither the glucose nor insulin levels. These results strongly suggest that 5-HT-induced hypoglycemia is brought on by increasing serum insulin levels.

MeSH terms

  • Animals
  • B-Lymphocytes / metabolism
  • Blood Glucose / metabolism*
  • Glucose / pharmacology
  • Hypoglycemia / chemically induced
  • Insulin / blood*
  • Insulin / metabolism
  • Male
  • Mice
  • Serotonin / adverse effects
  • Serotonin / pharmacology*
  • Streptozocin / pharmacology


  • Blood Glucose
  • Insulin
  • Serotonin
  • Streptozocin
  • Glucose