[Effects of melatonin in the brain of the senescence-accelerated mice-prone 8 (SAMP8) model]

Rev Neurol. 2011 May 16;52(10):618-22.
[Article in Spanish]


Senescence-accelerated mice (SAM) represent an aging model establish by selective inbreeding of the AKR/J strain. SAMP8 is a suitable model to study the genetics or proteics fundamental mechanisms of aging, in physiological or pathological conditions, because SAMP8 develop neuropathological markers also found in neurodegenerative diseases like Alzheimer. Melatonin is known as sleep hormone because its action controlling the sleep/awake circadian rhythm. Moreover, melatonin has antioxidant properties and may have an important anti-aging role. The chronic treatment with melatonin in the SAMP8 model was able to reduce oxidative stress and the neurodegenerative calpain/Cdk5 pathway and primed phosphorylation of GSK3beta and tau hiperphosphorylation markers of cerebral aging and neurodegeneration in SAMP8 brains, indicating the neuroprotective and anti-aging effect of melatonin.

Publication types

  • Review

MeSH terms

  • Aging / drug effects*
  • Aging / pathology
  • Aging / physiology
  • Animals
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use
  • Biomarkers / metabolism
  • Disease Models, Animal
  • Glycogen Synthase Kinase 3 / metabolism
  • Glycogen Synthase Kinase 3 beta
  • Melatonin / pharmacology*
  • Melatonin / therapeutic use*
  • Mice
  • Mice, Inbred Strains*
  • Neurodegenerative Diseases / drug therapy*
  • Neurodegenerative Diseases / pathology
  • Neurodegenerative Diseases / physiopathology
  • Neuroprotective Agents / pharmacology
  • Neuroprotective Agents / therapeutic use
  • Oxidative Stress / drug effects
  • tau Proteins / metabolism


  • Antioxidants
  • Biomarkers
  • Neuroprotective Agents
  • tau Proteins
  • Glycogen Synthase Kinase 3 beta
  • Gsk3b protein, mouse
  • Glycogen Synthase Kinase 3
  • Melatonin