Marianins A and B, prenylated phenylpropanoids from Mariannaea camptospora

J Nat Prod. 2011 May 27;74(5):1327-30. doi: 10.1021/np200035m. Epub 2011 Apr 13.

Abstract

Marianins A (1) and B (2), two new prenylated phenylpropanoids, were isolated from the culture extract of the fungus Mariannaea camptospora. Structures of marianins were elucidated by interpretation of NMR and other spectroscopic data. 1 is a 5-methylcoumarin bearing two prenyloxy groups, while 2 is an orcinol derivative substituted with a 3,3-dimethyl-4-pentenoyl chain. 2 is possibly derived from 1 through a Claisen rearrangement of the prenyl group, followed by lactone hydrolysis and decarboxylation. These compounds showed weak antibacterial activity against Micrococcus luteus.

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Hypocreales / chemistry*
  • Microbial Sensitivity Tests
  • Micrococcus luteus / drug effects*
  • Phenylpropionates / chemistry
  • Phenylpropionates / isolation & purification*
  • Phenylpropionates / pharmacology
  • Prenylation

Substances

  • Anti-Bacterial Agents
  • Phenylpropionates
  • marianin A
  • marianin B