What does biologically meaningful mean? A perspective on gene regulatory network validation

Genome Biol. 2011;12(4):109. doi: 10.1186/gb-2011-12-4-109. Epub 2011 Apr 11.


Gene regulatory networks (GRNs) are rapidly being delineated, but their quality and biological meaning are often questioned. Here, I argue that biological meaning is challenging to define and discuss reasons why GRN validation should be interpreted cautiously.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromatin Assembly and Disassembly / genetics
  • Computational Biology / methods*
  • Gene Expression Profiling
  • Gene Regulatory Networks / genetics*
  • Humans
  • Models, Biological
  • Research Design / statistics & numerical data
  • Transcription Factors / genetics*


  • Transcription Factors