Abstract
Kidney injury caused by immunoglobulin free light chains (FLCs) in the setting of plasma cell dyscrasias is common and associated with increased morbidity and mortality. All compartments of the kidney may be affected, from the glomerulus to the tubulointerstitium, in a wide variety of disease patterns. Here, we review our current knowledge of the biological effects of FLCs and the mechanisms that lead to kidney injury.
MeSH terms
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Animals
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Humans
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Immunoglobulin Light Chains / chemistry
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Immunoglobulin Light Chains / metabolism*
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Kidney / immunology*
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Kidney / pathology
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Kidney Diseases / immunology*
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Kidney Diseases / pathology
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Kidney Diseases / therapy
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Paraproteinemias / complications
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Paraproteinemias / immunology*
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Paraproteinemias / pathology
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Paraproteinemias / therapy
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Plasma Cells / immunology*
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Plasma Cells / pathology
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Protein Conformation
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Structure-Activity Relationship
Substances
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Immunoglobulin Light Chains