Proteins and renal fibrosis: low-protein diets induce Kruppel-like factor-15, limiting renal fibrosis

Kidney Int. 2011 May;79(9):933-4. doi: 10.1038/ki.2011.8.

Abstract

The mechanisms underlying beneficial influences of low-protein diets on the progressive nature of chronic kidney disease are incompletely understood. Gao et al. identify a downregulation of Kruppel-like factor-15 (KLF15) associated with increased renal fibrosis. The KLF15 downregulation and renal fibrosis are reversed with dietary protein restriction, especially when ketoacids are added. The results suggest that KLF15 may play a role in suppressing renal fibrosis and could contribute to the benefits of dietary protein restriction.

Publication types

  • Comment

MeSH terms

  • Animals
  • Chronic Disease
  • Diet, Protein-Restricted*
  • Fibrosis / prevention & control
  • Keto Acids / administration & dosage*
  • Kidney / pathology*
  • Kidney Diseases / diet therapy*
  • Kruppel-Like Transcription Factors / physiology*
  • Rats

Substances

  • Keto Acids
  • Klf15 protein, rat
  • Kruppel-Like Transcription Factors