Genome-wide Meta-Analysis Identifies Regions on 7p21 (AHR) and 15q24 (CYP1A2) as Determinants of Habitual Caffeine Consumption

PLoS Genet. 2011 Apr;7(4):e1002033. doi: 10.1371/journal.pgen.1002033. Epub 2011 Apr 7.

Abstract

We report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States. In a meta-analysis adjusted for age, sex, smoking, and eigenvectors of population variation, two loci achieved genome-wide significance: 7p21 (P = 2.4 × 10(-19)), near AHR, and 15q24 (P = 5.2 × 10(-14)), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2.

Publication types

  • Meta-Analysis
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Caffeine*
  • Chromosomes, Human, Pair 15 / genetics*
  • Chromosomes, Human, Pair 7 / genetics*
  • Cytochrome P-450 CYP1A2* / genetics
  • Cytochrome P-450 CYP1A2* / metabolism
  • Drinking Behavior / physiology*
  • European Continental Ancestry Group / genetics
  • Female
  • Genome-Wide Association Study*
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide / genetics
  • Quality Control
  • Receptors, Aryl Hydrocarbon / genetics
  • Receptors, Aryl Hydrocarbon / metabolism
  • Sex Factors
  • United States

Substances

  • Receptors, Aryl Hydrocarbon
  • Caffeine
  • Cytochrome P-450 CYP1A2

Grant support