Furanocoumarins from Dorstenia foetida

Ramona Heinke; Katrin Franke; Andrea Porzel; Ludger A Wessjohann; Nasser A Awadh Ali; Jürgen Schmidt

doi:10.1016/j.phytochem.2011.03.008

Furanocoumarins from Dorstenia foetida

Phytochemistry. 2011 Jun;72(9):929-34. doi: 10.1016/j.phytochem.2011.03.008. Epub 2011 Apr 12.

Authors

Ramona Heinke¹, Katrin Franke¹, Andrea Porzel¹, Ludger A Wessjohann¹, Nasser A Awadh Ali², Jürgen Schmidt¹

Affiliations

¹ Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, D-06120 Halle/Saale, Germany.
² Pharmacognosy Department, Faculty of Pharmacy, Sana'a University, P.O. Box 13150, Sana'a, Yemen.

PMID: 21492886
DOI: 10.1016/j.phytochem.2011.03.008

Abstract

The linear furanocoumarins 5-(2,3-epoxy-3-methyl-butoxy)-chalepensin, 5-methoxy-3-(3-methyl-2,3-dihydroxybutyl)-psoralen-diacetate (7), 5-methoxy-3-[3-(β-D-glucopyranosyloxy)-2-acetyloxy-3-methyl-butyl]-psoralen and 5-(3-methyl-2,3-dihydroxybutyloxy)-3-[3-(β-D-glucopyranosyloxy)-2-hydroxy-3-methyl-butyl]-psoralen, and the coumarin derivative 7-hydroxy-5-methoxy-6-carboxymethyl-3-[3-(β-D-glucopyranosyloxy)-2-hydroxy-3-methyl-butyl]-coumarin were isolated from the leaves of Dorstenia foetida (Moraceae) along with the known compounds psoralen, bergapten, isopimpinellin, phellopterin, 5-methoxychalepensin and turbinatocoumarin. Further furanocoumarins were characterized by ESI-MS/MS investigations. The nonpolar extracts of D. foetida exhibit antifungal, antibacterial and cytotoxic activity, however, no anthelminthic activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification
Antifungal Agents / chemistry
Antifungal Agents / isolation & purification
Cell Line, Tumor
Furocoumarins / chemistry*
Furocoumarins / isolation & purification
Humans
Molecular Structure
Moraceae / chemistry*
Plant Leaves / chemistry*

Substances

Anti-Bacterial Agents
Antifungal Agents
Furocoumarins