Aerosol therapy with thiamphenicol glycinate: a retrospective study on efficacy and safety in a group of sixty-six oncological patients

Int J Immunopathol Pharmacol. 2011 Jan-Mar;24(1):189-93. doi: 10.1177/039463201102400122.

Abstract

The purpose of this paper is to present the effectiveness of aerosol administration of TG in a group of oncological patients. Thiamphenicol is an antimicrobial agent active in the treatment of infection of different etiology and localisation due to its broad spectrum of antimicrobial activity as well as its pharmacokinetic properties. The data of the retrospective study analysis of the activity of TG, administered to oncological patients affected by infections of the respiratory tract, showed that TG administered alone or in association with other antibiotics was globally effective in more than 95% of patients. These positive results were obtained in immunologically compromised patients. The therapeutic advantages of using TG are: ease of use - aerosol therapy permits good local action; tolerability - no adverse reaction or intolerance; the possibility of using it in an ideal association with other antibiotics to combat the infectious pathology.

MeSH terms

  • Adult
  • Aerosols
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / administration & dosage*
  • Female
  • Head and Neck Neoplasms / complications*
  • Humans
  • Male
  • Middle Aged
  • Respiratory Tract Infections / drug therapy*
  • Retrospective Studies
  • Thiamphenicol / administration & dosage
  • Thiamphenicol / adverse effects
  • Thiamphenicol / analogs & derivatives*
  • Thiamphenicol / pharmacology

Substances

  • Aerosols
  • Anti-Bacterial Agents
  • Thiamphenicol
  • thiamphenicol glycinate