Human resistin: found in translation from mouse to man

Trends Endocrinol Metab. 2011 Jul;22(7):259-65. doi: 10.1016/j.tem.2011.03.005. Epub 2011 Apr 15.


The discovery of resistin 10 years ago as a fat cell-secreted factor that modulates insulin resistance suggested a link to the current obesity-associated epidemics of diabetes and cardiovascular disease, which are major human health concerns. Although adipocyte-derived resistin is indisputably linked to insulin resistance in rodent models, the relevance of human resistin is complicated because human resistin is secreted by macrophages rather than adipocytes, and because of the descriptive nature of human epidemiology. In this review, we examine the recent and growing evidence that human resistin is an inflammatory biomarker and a potential mediator of diabetes and cardiovascular disease.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adipocytes, White / immunology
  • Adipocytes, White / metabolism
  • Animals
  • Cardiovascular Diseases / metabolism
  • Diabetes Mellitus, Type 2 / metabolism
  • Humans
  • Inflammation Mediators / blood
  • Inflammation Mediators / metabolism
  • Insulin Resistance
  • Macrophages / immunology
  • Macrophages / metabolism
  • Mice
  • Obesity / metabolism
  • Resistin / blood
  • Resistin / metabolism*
  • Species Specificity


  • Inflammation Mediators
  • RETN protein, human
  • Resistin
  • Retn protein, mouse