Prognostic benefits of lymph node dissection have been proven for patients with breast cancer or gynecological malignancies; however, one of the complications associated with this procedure is lymphedema. We reviewed therapies for secondary lymphedema, including complex decongestive physiotherapy, skin care, manual lymphatic drainage, compression bandaging and garments, and limb exercises. The challenge to secondary lymphedema in Jikei University Hospital, consisting of Aggressive Protocol for Patients with LymphedemA Using SophisticatEd methods(APPLAUSE)has been implemented. Jikei Lymphedema Assessment Scale(JLA-Se)and the LPG technic®, have also been introduced.