Gusanlungionosides A-D, potential tyrosinase inhibitors from Arcangelisia gusanlung

J Nat Prod. 2011 May 27;74(5):1009-14. doi: 10.1021/np100900k. Epub 2011 Apr 18.

Abstract

Four new megastigmane glycosides, named gusanlungionosides A-D (1-4), together with 10 known compounds (5-14), were isolated from the stems of Arcangelisia gusanlung. The structures and absolute configurations of 1-4 were elucidated by comprehensive analysis of their NMR and CD data. Compounds 1-4 exhibited strong inhibitory effects not only on the mushroom tyrosinase activity in vitro but also on melanogenesis in cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Agaricales
  • Animals
  • Base Sequence
  • Cyclohexanones / chemistry
  • Cyclohexanones / isolation & purification*
  • Cyclohexanones / pharmacology*
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology*
  • Glucosides / chemistry
  • Glucosides / isolation & purification*
  • Glucosides / pharmacology*
  • Glycosides / chemistry
  • Glycosides / isolation & purification*
  • Glycosides / pharmacology*
  • Melanins / antagonists & inhibitors*
  • Melanins / biosynthesis
  • Menispermaceae / chemistry*
  • Mice
  • Molecular Structure
  • Monophenol Monooxygenase / antagonists & inhibitors*
  • Norisoprenoids / chemistry
  • Norisoprenoids / isolation & purification*
  • Norisoprenoids / pharmacology*
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Stems / chemistry

Substances

  • Cyclohexanones
  • Drugs, Chinese Herbal
  • Glucosides
  • Glycosides
  • Melanins
  • Norisoprenoids
  • megastigmane
  • Monophenol Monooxygenase