Abstract
Four new megastigmane glycosides, named gusanlungionosides A-D (1-4), together with 10 known compounds (5-14), were isolated from the stems of Arcangelisia gusanlung. The structures and absolute configurations of 1-4 were elucidated by comprehensive analysis of their NMR and CD data. Compounds 1-4 exhibited strong inhibitory effects not only on the mushroom tyrosinase activity in vitro but also on melanogenesis in cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Agaricales
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Animals
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Base Sequence
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Cyclohexanones / chemistry
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Cyclohexanones / isolation & purification*
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Cyclohexanones / pharmacology*
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology*
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Glucosides / chemistry
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Glucosides / isolation & purification*
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Glucosides / pharmacology*
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology*
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Melanins / antagonists & inhibitors*
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Melanins / biosynthesis
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Menispermaceae / chemistry*
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Mice
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Molecular Structure
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Monophenol Monooxygenase / antagonists & inhibitors*
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Norisoprenoids / chemistry
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Norisoprenoids / isolation & purification*
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Norisoprenoids / pharmacology*
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Nuclear Magnetic Resonance, Biomolecular
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Plant Stems / chemistry
Substances
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Cyclohexanones
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Drugs, Chinese Herbal
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Glucosides
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Glycosides
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Melanins
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Norisoprenoids
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megastigmane
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Monophenol Monooxygenase