Induction and prevention of radiocontrast-induced nephropathy in dogs with heart failure

Kidney Int. 1990 Dec;38(6):1101-8. doi: 10.1038/ki.1990.319.


Radiocontrast-induced nephropathy (RCIN) is a clinically important cause of acute renal failure with no effective treatment. Recognizing the high incidence of RCIN in humans with severe congestive heart failure (CHF), this study was designed to test the hypotheses that dogs with experimental CHF are at increased risk for RCIN and that pharmacologic renal levels of atrial natriuretic factor (ANF) can prevent RCIN in this model. In chronic experiments, three groups of five conscious dogs received intravenous radiocontrast (7 ml/kg). One group consisted of normal controls, while the two other groups had experimental CHF induced by eight days of ventricular pacing at 250 beats per minute. One of the CHF groups received an infusion of ANF (30 ng/kg/min) into the suprarenal aorta for one hour before, during and after the infusion of radiocontrast to achieve pharmacologic renal plasma levels. Renal function remained stable in the normal controls in contrast to the consistent decreases in daily creatinine clearance during the five days following radiocontrast in experimental CHF. In addition, ANF prevented radiocontrast-induced reductions in creatinine clearance in dogs with experimental CHF. Additional studies performed in two groups of anesthetized dogs with experimental CHF demonstrated that, in this model of RCIN, the reduction in renal function appears biphasic, and the action of ANF may be to increase glomerular filtration rate prior to radiocontrast, thus allowing a maintenance of renal function during and after radiocontrast.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acute Kidney Injury / chemically induced*
  • Acute Kidney Injury / prevention & control
  • Animals
  • Atrial Natriuretic Factor / therapeutic use*
  • Cardiac Pacing, Artificial
  • Contrast Media / toxicity*
  • Dogs
  • Drug Combinations
  • Female
  • Glomerular Filtration Rate / drug effects
  • Heart Failure / etiology
  • Heart Failure / physiopathology*
  • Iothalamate Meglumine / toxicity*
  • Iothalamic Acid / toxicity*
  • Male


  • Contrast Media
  • Drug Combinations
  • Iothalamic Acid
  • Vascoray
  • Atrial Natriuretic Factor
  • Iothalamate Meglumine