Immunologic considerations for generating memory CD8 T cells through vaccination

Cell Microbiol. 2011 Jul;13(7):925-33. doi: 10.1111/j.1462-5822.2011.01594.x. Epub 2011 Apr 28.


Following infection or vaccination, naïve CD8 T cells that receive the appropriate integration of antigenic, co-stimulatory and inflammatory signals undergo a programmed series of biological changes that ultimately results in the generation of memory cells. Memory CD8 T cells, in contrast to naïve cells, more effectively limit or prevent pathogen re-infection because of both qualitative and quantitative changes that occur following their induction. Unlike vaccination strategies aimed at generating antibody production, the ability to generate protective memory CD8 T cells has proven more complicated and problematic. However, recent experimental results have revealed important principles regarding the molecular and genetic basis for memory CD8 T cell formation, as well as identified ways to manipulate their development through vaccination, resulting in potential new avenues to enhance protective immunity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • CD8-Positive T-Lymphocytes / immunology*
  • Humans
  • Immunologic Memory*
  • Models, Biological
  • Vaccination / methods*
  • Vaccines / immunology*


  • Vaccines