The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics

Cold Spring Harb Symp Quant Biol. 2010;75:35-42. doi: 10.1101/sqb.2010.75.063. Epub 2011 Apr 18.


The evolutionarily conserved INO80 family of ATP-dependent chromatin-remodeling enzymes has roles in many nuclear processes, including transcription, DNA repair, and DNA replication. Here, we discuss the in vivo and in vitro properties of these enzymes, focusing on recent studies which suggest that members of this family govern the deposition and removal of the histone variant H2A.Z.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Chromatin Assembly and Disassembly*
  • DNA Helicases / chemistry
  • DNA Helicases / genetics
  • DNA Helicases / metabolism*
  • Histones / metabolism*
  • Humans
  • Models, Biological
  • Protein Isoforms / metabolism
  • Protein Subunits / metabolism


  • Histones
  • Protein Isoforms
  • Protein Subunits
  • DNA Helicases