Perioperative Hyperoxygenation and Wound Site Infection Following Surgery for Acute Appendicitis: A Randomized, Prospective, Controlled Trial

Arch Surg. 2011 Apr;146(4):464-70. doi: 10.1001/archsurg.2011.65.


Objective: To assess the influence of hyperoxygenation on surgical site infection by using the most homogeneous study population.

Design: A randomized, prospective, controlled trial.

Setting: Department of surgery in a government hospital.

Patients: A total of 210 patients who underwent open surgery for acute appendicitis. In the study group, patients received 80% oxygen during anesthesia, followed by high-flow oxygen for 2 hours in the recovery room. The control group received 30% oxygen, as usual.

Intervention: Open appendectomy via incision in the right lower quadrant of the abdomen.

Main outcome measures: Surgical site infection, mainly assessed by the ASEPSIS (additional treatment, serous discharge, erythema, purulent discharge, separation of deep tissues, isolation of bacteria, and stay in hospital prolonged >14 days) system score.

Results: Surgical site infections were recorded in 6 of 107 patients (5.6%) in the study group vs 14 of 103 patients (13.6%) in the control group (P = .04). Significant differences in the ASEPSIS score were also found. The mean hospital stay was longer in the control group (2.92 days) compared with the study group (2.51 days) (P = .01).

Conclusion: The use of supplemental oxygen is advantageous in operations for acute appendicitis by reducing surgical site infection rate and hospital stay.

Trial registration: Identifier: NCT01002365.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Appendectomy* / adverse effects
  • Appendicitis / diagnosis
  • Appendicitis / surgery*
  • Female
  • Humans
  • Length of Stay / statistics & numerical data*
  • Male
  • Middle Aged
  • Oxygen / administration & dosage*
  • Perioperative Period*
  • Prospective Studies
  • Surgical Wound Infection / prevention & control*
  • Treatment Outcome
  • Young Adult


  • Oxygen

Associated data