Mechanisms and functions of Hedgehog signalling across the metazoa

Nat Rev Genet. 2011 Jun;12(6):393-406. doi: 10.1038/nrg2984. Epub 2011 Apr 19.


Hedgehog proteins constitute one of a small number of families of secreted signals that have a central role in the development of metazoans. Genetic analyses in flies, fish and mice have uncovered the major components of the pathway that transduces Hedgehog signals, and recent genome sequence projects have provided clues about its evolutionary origins. In this Review we provide an updated overview of the mechanisms and functions of this signalling pathway, highlighting the conserved and divergent features of the pathway, as well as some of the common themes in its deployment that have emerged from recent studies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cilia / metabolism
  • Drosophila melanogaster
  • Gene Expression Regulation*
  • Genome
  • Hedgehog Proteins / genetics
  • Hedgehog Proteins / metabolism*
  • Humans
  • Ligands
  • Lipids / chemistry
  • Mice
  • Models, Genetic
  • Phylogeny
  • Protein Structure, Tertiary
  • Signal Transduction
  • Transcription Factors / metabolism


  • Hedgehog Proteins
  • Ligands
  • Lipids
  • Transcription Factors