Pointing in the right direction: new developments in the field of planar cell polarity

Nat Rev Genet. 2011 Jun;12(6):385-91. doi: 10.1038/nrg2956. Epub 2011 Apr 19.

Abstract

Planar cell polarity (PCP) is observed in an array of developmental processes that involve collective cell movement and tissue organization, and its disruption can lead to severe developmental defects. Recent studies in flies and vertebrates have identified new functions for PCP as well as new signalling components, and have proposed new mechanistic models. However, despite this progress, the search to simplify principles of understanding continues and important mechanistic uncertainties still pose formidable challenges.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Movement
  • Cell Polarity*
  • Cilia / metabolism
  • DNA-Binding Proteins / metabolism
  • Drosophila Proteins / metabolism
  • Drosophila melanogaster
  • Epidermis / metabolism
  • Humans
  • Models, Genetic
  • Septins / metabolism
  • Signal Transduction
  • Transcription Factors / metabolism
  • Wound Healing

Substances

  • DNA-Binding Proteins
  • Drosophila Proteins
  • Transcription Factors
  • grh protein, Drosophila
  • Septins