Intracranial aneurysm coiling with PGLA-coated coils versus bare platinum coils: long-term anatomic follow-up

Neuroradiology. 2012 Apr;54(4):345-8. doi: 10.1007/s00234-011-0870-2. Epub 2011 Apr 19.


Introduction: The purpose of this study is to compare the long-term (≥12 months) angiographic follow-up of aneurysms treated with polymer polyglycolic-lactic acid (PGLA)-coated coils versus bare platinum coils.

Methods: Long-term angiographic follow-up results of 90 aneurysms treated exclusively with PGLA-coated coils were retrospectively analyzed and compared to those of 158 aneurysms treated exclusively with bare platinum coils.

Results: There were 32 ruptured aneurysms (35.5%) in the PGLA-coated coil group and 62 (39.2%) in the bare platinum coil group. The mean angiographic follow-up was 29 months in the PGLA-coated coil group versus 27 months in the bare platinum coil group (P = 0.2297). The mean time to angiographic recurrence was 14 months in the PGLA-coated coil group versus 18 months in the bare platinum coil group (P = 0.1088). Recurrence rates were 35.6% (32/90) and 31.0% (49/158) in the PGLA-coated coil and bare platinum coil groups, respectively (P = 0.4837). The major recurrence justifying retreatment was 5.6% (5/90) in the PGLA-coated coil group versus 6.7% (10/158) in the bare platinum coil group (P = 1.000).

Conclusion: PGLA-coated coils provided no better long-term recanalization rates than bare platinum coils.

Publication types

  • Comparative Study

MeSH terms

  • Aneurysm, Ruptured / diagnostic imaging*
  • Aneurysm, Ruptured / therapy*
  • Cerebral Angiography*
  • Coated Materials, Biocompatible
  • Embolization, Therapeutic / instrumentation*
  • Female
  • Follow-Up Studies
  • Humans
  • Intracranial Aneurysm / diagnostic imaging*
  • Intracranial Aneurysm / therapy*
  • Logistic Models
  • Male
  • Middle Aged
  • Platinum
  • Polyglycolic Acid
  • Radiography, Interventional
  • Recurrence
  • Retrospective Studies
  • Statistics, Nonparametric
  • Treatment Outcome


  • Coated Materials, Biocompatible
  • Polyglycolic Acid
  • Platinum