[Treatment of crow's feet with two different botulinum toxin type A preparations in split-face technique]

Hautarzt. 2011 May;62(5):375-9. doi: 10.1007/s00105-011-2148-3.
[Article in German]


Background: For the first time, the effectiveness of Xeomin®, and Dysport® in an dose-ratio of 1:3 treating crow's feet (FWS 2-3) was evaluated in a double-blind randomized pilot study.

Patients and method: Xeomin® (12 units) was compared to Dysport® (36 units) in an intra-individual split-face technique in 22 patients over a period of 4 months. According to the facial-wrinkle-scale (FWS) patients were rated as responders with an improvement of at least 1 point in FWS.

Results: One month after treatment significantly more than 80% of patients were rated as responders. The different products proved to be equivalent in response rate and effectiveness with no significant difference after 4 weeks and 4 months in statistical analysis. Surprisingly the decrease in FWS of crows' feet at rest was more pronounced.

Conclusion: The different botulinum toxin type A formulations proved to be equivalent in effectiveness and tolerability in a dose ratio of 1:3 (Xeomin®: Dysport®) The more pronounced decrease of crow's feet at rest points out the importance of muscle insertion into the skin for the cosmetic result in the periorbital region.

Publication types

  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Botulinum Toxins, Type A / therapeutic use*
  • Dermatologic Agents / therapeutic use
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Neuromuscular Agents / therapeutic use
  • Skin / anatomy & histology*
  • Skin / drug effects*
  • Skin Aging / drug effects*
  • Treatment Outcome


  • Dermatologic Agents
  • Neuromuscular Agents
  • Botulinum Toxins, Type A