Enhancement of psychotherapy using epigenetic modulating drugs

Med Hypotheses. 2011 Jul;77(1):121-4. doi: 10.1016/j.mehy.2011.03.042. Epub 2011 Apr 19.


Recent evidence suggests that covalent modifications to the genomic platform in the brain, that is DNA and its surrounding histones, provide a stable potentially lifelong mechanism for remembrance. Consequently, the making and unmaking of memories is accessible through pharmacological manipulations of these modifications. This has implications for psychotherapy and long-term rehabilitation of CNS disorders. We hypothesize that by enhancing learning through pharmacologically manipulating 'epigenetic' parameters, the effects of psychotherapies and rehabilitation can be enhanced.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Central Nervous System Diseases / psychology
  • Central Nervous System Diseases / therapy
  • Epigenesis, Genetic / drug effects*
  • Histone Deacetylase Inhibitors / pharmacology
  • Humans
  • Psychotherapy*


  • Histone Deacetylase Inhibitors