Manipulating DNA writhe through varying DNA sequences

Chem Commun (Camb). 2011 Jul 14;47(26):7479-81. doi: 10.1039/c1cc11543j. Epub 2011 Apr 20.

Abstract

It is demonstrated that the shapes and magnitudes of DNA writhe can be precisely manipulated solely through maneuvering the nucleotide sequence of DNA and without the assistance of topoisomerases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacteriophage T4
  • Base Sequence
  • DNA / chemical synthesis
  • DNA / chemistry*
  • DNA / genetics*
  • Feasibility Studies
  • Nucleic Acid Conformation*

Substances

  • DNA