Mediterranean diet and oxidation: nuts and olive oil as important sources of fat and antioxidants

Curr Top Med Chem. 2011;11(14):1797-810. doi: 10.2174/156802611796235062.


Oxidative stress has been involved in the aetiology of hypertension, insulin resistance, the metabolic syndrome, cardiovascular disease and other chronic conditions. Several epidemiological studies suggest that a diet rich in natural antioxidants is associated with protective effects against major diseases, especially cardiovascular disease. The Mediterranean diet is rich in fat and foods with important antioxidant properties, such as fruits and vegetables, olive oil, and nuts. In this review we focus on epidemiological evidence and clinical trials that relate the Mediterranean diet with oxidative stress markers. We focus our review on two important Mediterranean vegetable sources of potentially oxidized fat-olive oil and nuts.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / drug therapy*
  • Cardiovascular Diseases / physiopathology
  • Cardiovascular Diseases / prevention & control
  • Clinical Trials as Topic
  • Diet, Mediterranean*
  • Free Radical Scavengers / pharmacology*
  • Free Radicals / antagonists & inhibitors*
  • Free Radicals / metabolism
  • Humans
  • Metabolic Syndrome / drug therapy*
  • Metabolic Syndrome / physiopathology
  • Metabolic Syndrome / prevention & control
  • Mice
  • Nuts / chemistry
  • Nuts / metabolism*
  • Olive Oil
  • Oxidation-Reduction / drug effects
  • Oxidative Stress / drug effects
  • Plant Oils / chemistry
  • Plant Oils / pharmacology*
  • Risk Factors


  • Free Radical Scavengers
  • Free Radicals
  • Olive Oil
  • Plant Oils