Impact of smoking, physical training and weight reduction on FVII, PAI-1 and hemostatic markers in sedentary men

Thromb Haemost. 1990 Dec 28;64(4):516-20.


The variations of FVII, PAI-1, TAT complexes, fibrinopeptide A, D-Dimers and beta thromboglobulin plasma levels were studied on 30 sedentary men, smokers and non-smokers, who were admitted to a 6 months' program of physical training and smoking cessation. After 3 months of intervention, sustained physical training was associated with the decrease of FVII and PAI-1 levels. Mild exercise performed during a second 3-month period could maintain normal FVII and PAI-1 activities but participants who stopped the training increased their FVII and PAI-1 plasma levels. FVII was not influenced by smoking habits. Smoking cessation seemed to slightly potentiate the decrease of PAI-1 levels associated with mild exercise. Overweight, FVII and PAI-1 levels were correlated and the weight reduction induced by training was related to the changes in the factors. In smokers, physical exercise was associated with a significant increase of hemostatic markers. This exercise-induced variation disappeared after 3 months of intervention in participants who stopped smoking and reappeared in those who smoked again after 6 months of intervention. This finding was not influenced by the physical training program.

MeSH terms

  • Antithrombin III / metabolism
  • Biomarkers / blood
  • Factor VII / metabolism
  • Fibrin Fibrinogen Degradation Products / metabolism
  • Fibrinopeptide A / metabolism
  • Hemostasis / physiology*
  • Humans
  • Male
  • Peptide Hydrolases / metabolism
  • Physical Education and Training*
  • Plasminogen Inactivators / blood
  • Reproducibility of Results
  • Smoking / blood*
  • Weight Loss / physiology*
  • beta-Thromboglobulin / metabolism


  • Biomarkers
  • Fibrin Fibrinogen Degradation Products
  • Plasminogen Inactivators
  • antithrombin III-protease complex
  • beta-Thromboglobulin
  • fibrin fragment D
  • Fibrinopeptide A
  • Antithrombin III
  • Factor VII
  • Peptide Hydrolases