Impact of preterm PROM and its complications on long-term infant outcomes

Clin Obstet Gynecol. 2011 Jun;54(2):358-69. doi: 10.1097/GRF.0b013e318217ee18.


There is increasing evidence that preterm premature rupture of membranes (PPROM) is associated with increased risk for adverse neurodevelopmental outcomes through multiple mechanisms, including preterm birth and its antecedent etiologies. Intrauterine infection is a particularly important risk factor for adverse neurodevelopmental outcomes after PPROM. This review focuses on the long-term neurodevelopmental outcomes after PPROM, the possible etiologic mechanisms of neurological injury, and the effect of antenatal and perinatal interventions using available evidence.

Publication types

  • Review

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Cytokines / adverse effects
  • Cytokines / metabolism
  • Female
  • Fetal Membranes, Premature Rupture* / drug therapy
  • Fetal Membranes, Premature Rupture* / genetics
  • Fetal Membranes, Premature Rupture* / microbiology
  • Fetal Membranes, Premature Rupture* / physiopathology
  • Genetic Predisposition to Disease
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Inflammation / metabolism
  • Magnesium Sulfate / therapeutic use
  • Nervous System Diseases / etiology*
  • Pregnancy
  • Premature Birth*
  • Prognosis
  • Time Factors
  • Tocolytic Agents / therapeutic use


  • Adrenal Cortex Hormones
  • Cytokines
  • Tocolytic Agents
  • Magnesium Sulfate