Modelling the role of Tax expression in HTLV-I persistence in vivo

Bull Math Biol. 2011 Dec;73(12):3008-29. doi: 10.1007/s11538-011-9657-1. Epub 2011 Apr 21.


Human T-lymphotropic virus type I (HTLV-I) is a persistent human retrovirus characterized by life-long infection and risk of developing HAM/TSP, a progressive neurological and inflammatory disease, and adult T-cell leukemia (ATL). Chronically infected individuals often harbor high proviral loads despite maintaining a persistently activated immune response. Based on a new hypothesis for the persistence of HTLV-I infection, a three-dimensional compartmental model is constructed that describes the dynamic interactions among latently infected target cells, target-cell activation, and immune responses to HTLV-I, with an emphasis on understanding the role of Tax expression in the persistence of HTLV-I.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Gene Expression
  • Gene Products, tax / genetics
  • Genes, pX*
  • HTLV-I Infections / genetics*
  • HTLV-I Infections / immunology
  • HTLV-I Infections / virology*
  • Human T-lymphotropic virus 1 / genetics
  • Human T-lymphotropic virus 1 / immunology
  • Humans
  • Mathematical Concepts
  • Models, Biological
  • Viral Load


  • Gene Products, tax
  • tax protein, Human T-lymphotrophic virus 1