Dynamic lineage analysis of embryonic morphogenesis using transgenic quail and 4D multispectral imaging

Genesis. 2011 Jul;49(7):619-43. doi: 10.1002/dvg.20754. Epub 2011 Jun 17.


We describe the development of transgenic quail that express various fluorescent proteins in targeted manners and their use as a model system that integrates advanced imaging approaches with conventional and emerging molecular genetics technologies. We also review the progression and complications of past fate mapping techniques that led us to generate transgenic quail, which permit dynamic imaging of amniote embryogenesis with unprecedented subcellular resolution.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Animals, Genetically Modified
  • Cell Lineage / genetics*
  • Embryo, Nonmammalian / cytology
  • Embryo, Nonmammalian / metabolism
  • Embryonic Development / genetics*
  • Luminescent Proteins / genetics
  • Luminescent Proteins / metabolism
  • Molecular Imaging*
  • Morphogenesis / genetics*
  • Protein Transport / genetics
  • Quail / embryology
  • Quail / genetics
  • Time-Lapse Imaging*


  • Luminescent Proteins