Endoscopic features of sessile serrated adenoma and other serrated colorectal polyps

Hepatogastroenterology. 2011 Jan-Feb;58(105):45-51.


Background/aims: Sessile serrated adenoma is a subtype of serrated colorectal polyps that can potentially give rise to colorectal carcinoma. We aimed to characterize the endoscopic features of sessile serrated adenoma as compared to those of other subtypes of serrated colorectal polyps.

Methodology: A total of 202 serrated colorectal polyps were retrospectively collected and pathologically subclassified as sessile serrated adenoma, hyperplastic polyp, or traditional serrated adenoma. The patients' demographics and endoscopic findings were reviewed, and comparisons were made between groups.

Results: We found 57 sessile serrated adenomas, 104 hyperplastic polyps, and 41 traditional serrated adenomas. Sessile serrated adenomas were larger in size, and they had more granular or nodular surface and more irregular or vague margin than hyperplastic polyps; however, these two subgroups were similar in terms of their sessile configuration and white coloring. Sessile serrated adenomas could be distinguished from traditional serrated adenomas based on the pedunculated configuration and red coloring unique to the traditional serrated adenomas. Nine sessile serrated adenomas were of note due to coverage with abundant mucus, which was rarely seen in other subgroups.

Conclusions: We characterize the endoscopic features of sessile serrated adenoma as compared to those of hyperplastic polyp and traditional serrated adenoma.

MeSH terms

  • Adenoma / pathology*
  • Aged
  • Colonic Polyps / pathology*
  • Colonoscopy*
  • Colorectal Neoplasms / pathology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Staining and Labeling