Malignancies following lung transplantation

Clin Chest Med. 2011 Jun;32(2):343-55. doi: 10.1016/j.ccm.2011.02.011. Epub 2011 Mar 22.

Abstract

Malignancy is an important complication of thoracic organ transplantation and is associated with significant morbidity and mortality. Lung transplant recipients are at greater risk for cancer than immunocompetent persons, with cancer-specific incidence rates up to 60-fold higher than the general population. The increased risk for cancer is attributed to neoplastic properties of immunosuppressive medications, oncogenic viruses, and cancer-specific risk factors. This article addresses the epidemiology, presentation, and treatment of the most common malignancies after lung transplantation, including skin cancer, posttransplant lymphoproliferative disorder, and bronchogenic carcinoma.

Publication types

  • Review

MeSH terms

  • Carcinoma, Basal Cell / diagnosis
  • Carcinoma, Basal Cell / etiology
  • Carcinoma, Basal Cell / therapy
  • Carcinoma, Bronchogenic / diagnosis
  • Carcinoma, Bronchogenic / etiology
  • Carcinoma, Bronchogenic / therapy
  • Carcinoma, Squamous Cell / diagnosis
  • Carcinoma, Squamous Cell / etiology
  • Carcinoma, Squamous Cell / therapy
  • Humans
  • Lung Neoplasms / diagnosis
  • Lung Neoplasms / epidemiology
  • Lung Neoplasms / etiology*
  • Lung Neoplasms / therapy
  • Lung Transplantation*
  • Lymphoproliferative Disorders / diagnosis
  • Lymphoproliferative Disorders / etiology*
  • Lymphoproliferative Disorders / therapy
  • Postoperative Complications* / diagnosis
  • Postoperative Complications* / therapy
  • Risk Factors
  • Skin Neoplasms / diagnosis
  • Skin Neoplasms / etiology*
  • Skin Neoplasms / therapy