Getting closer to the dirty little secret

Immunity. 2011 Apr 22;34(4):455-8. doi: 10.1016/j.immuni.2011.04.003.


The molecular mechanism behind alum adjuvanticity is probably the oldest secret of immunology. In this issue of Immunity, Kuroda et al. (2011) and Kool et al. (2011) identify NLRP3 inflammasome-independent signaling to be crucial for the Th2 cell response induced by aluminum salts.

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