Birth of a healthy infant after intracytoplasmic sperm injection using pentoxifylline-activated sperm from a patient with Kartagener's syndrome

Abstract

Objective: To describe the delivery of a healthy female infant after intracytoplasmic sperm injection (ICSI) using pentoxifylline-activated sperm from a patient with Kartagener's syndrome.

Design: Case report.

Setting: Private assisted reproductive technology clinic in Japan.

Patient(s): A couple with male factor infertility due to Kartagener's syndrome.

Intervention(s): Intracytoplasmic sperm injection using ejaculated sperm activated by pentoxifylline.

Main outcome measure(s): Semen characteristics, sperm ultrastructure, fertilization, pregnancy, and birth after ICSI.

Result(s): The fertilization rate was 7 of 12 (58.3%), and the blastocyst formation rate was 4 of 7 (57.1%); all blastocysts were vitrified. After a single blastcyst transfer, a pregnancy ensued and progressed to term; a healthy female infant was delivered.

Conclusion(s): With ejaculated sperm, which was activated by pentoxifylline, successful fertilization was accomplished by ICSI; thus, fertilization, vitrification, pregnancy, and delivery are attainable with sperm obtained from men with Kartagener's syndrome.