Osteonecrosis in children after therapy for malignancy
- PMID: 21512065
- PMCID: PMC4700933
- DOI: 10.2214/AJR.10.6073
Osteonecrosis in children after therapy for malignancy
Abstract
Objective: Osteonecrosis in the growing population of childhood cancer survivors results from disease and treatment. Imagers must be knowledgeable about patient groups at risk for its development, patterns of involvement and potential implications. This review will focus on implications of this potentially life-altering toxicity.
Conclusion: Childhood cancer survivors are at increased risk for developing osteonecrosis. Because osteonecrosis is often asymptomatic until late in the process, imaging is critical for its detection and characterization when interventions may be most effective to ameliorate its progression.
Figures
Similar articles
-
Osteonecrosis in pediatric cancer survivors: Epidemiology, risk factors, and treatment.Surg Oncol. 2019 Mar;28:214-221. doi: 10.1016/j.suronc.2019.02.001. Epub 2019 Feb 4. Surg Oncol. 2019. PMID: 30851903 Review.
-
[Pathogenesis and treatment of spontaneous osteonecroses (author's transl)].Orthopade. 1981 Jan;10(1):19-39. Orthopade. 1981. PMID: 7017545 Review. German. No abstract available.
-
Osteonecrosis after renal transplantation in children.J Bone Joint Surg Am. 1979 Sep;61(6A):851-6. J Bone Joint Surg Am. 1979. PMID: 383717
-
Avascular bone necrosis of the hip joint after solid organ transplantation in childhood: a clinical and MRI analysis.Transplantation. 2006 Jun 27;81(12):1621-7. doi: 10.1097/01.tp.0000226062.36325.4b. Transplantation. 2006. PMID: 16794525
-
Osteonecrosis in children after allogeneic hematopoietic cell transplantation: study of prevalence, risk factors and longitudinal changes using MR imaging.Bone Marrow Transplant. 2012 Aug;47(8):1067-74. doi: 10.1038/bmt.2011.234. Epub 2011 Dec 12. Bone Marrow Transplant. 2012. PMID: 22158389 Free PMC article. Clinical Trial.
Cited by
-
Physical impairments, activity limitations, and participation restrictions of childhood acute lymphoblastic leukemia survivors with and without hip osteonecrosis: a PETALE cohort study.J Cancer Surviv. 2024 May 24. doi: 10.1007/s11764-024-01585-4. Online ahead of print. J Cancer Surviv. 2024. PMID: 38787491
-
Talus Avascular Necrosis as a Rare Complication of Cushing's Disease: A Case Report.Cureus. 2024 Apr 3;16(4):e57531. doi: 10.7759/cureus.57531. eCollection 2024 Apr. Cureus. 2024. PMID: 38707157 Free PMC article.
-
A Review of Late Effects in Pediatric Cancer: Implications for Rehabilitation.Rehabil Oncol. 2023 Oct;41(4):215-218. doi: 10.1097/01.reo.0000000000000351. Epub 2023 Oct 2. Rehabil Oncol. 2023. PMID: 38524881 Free PMC article. No abstract available.
-
Review of the Pathogenesis, Diagnosis, and Management of Osteoradionecrosis of the Femoral Head.Med Sci Monit. 2023 Jun 13;29:e940264. doi: 10.12659/MSM.940264. Med Sci Monit. 2023. PMID: 37310931 Free PMC article.
-
Functional Outcomes for Children, Adolescents, and Young Adults with Osteonecrosis following Hip Core Decompression.Rehabil Oncol. 2022 Oct;40(4):E46-E53. doi: 10.1097/01.reo.0000000000000306. Epub 2022 Jul 20. Rehabil Oncol. 2022. PMID: 36876164 Free PMC article.
References
-
- National Institute of Arthritis and Musculoskeletal and Skin Diseases Website. [Accessed December 10, 2010];Osteonecrosis. www.niams.nih.gov/Health_Info/Osteonecrosis/default.asp. Published June 2009.
-
- Mont MA, Jones LC, Hungerford DS. Non-traumatic osteonecrosis of the femoral head: ten years later. J Bone Joint Surg Am. 2006;88:1117–1132. - PubMed
-
- Karimova EJ, Rai SN, Ingle D, et al. MRI of knee osteonecrosis in children with leukemia and lymphoma. Part 2. Clinical and imaging patterns. AJR. 2006;186:477–482. - PubMed
-
- Niinimaki RA, Harila-Saari AH, Jartti AE, et al. Osteonecrosis in children treated for lymphoma or solid tumors. J Pediatr Hematol Oncol. 2008;30:798–802. - PubMed
-
- Gardeniers JWM. The ARCO perspective for reaching one uniform staging system of osteonecrosis. In: Schoutens A, Arlet J, Gardeniers JWM, et al., editors. Bone circulation and vascularization in normal and pathological conditions. New York, NY: Plenum Press; 1993. pp. 375–380.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
