[Effects of the enkephalins on natural killer cytotoxicity]

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1990 Dec;12(6):457-60.
[Article in Chinese]


Spleen mononuclear cells of BALB/C mice and YAC-1 cells were used in this experiment. Leucine enkephalin or methionine enkephalin at time 0 was added to cell cultures and the amount of the enzyme lactate dehydrogenase released from lysed target cells was determined 22 hours after incubation. There were on average 41% (5% to 60.7%) and 63% (46.8% to 78%) enhancements of natural killer activity in the presence of leucine enkephalin (1 x 10(-11)-1 x 10(-3) mg/ml) and methionine enkephalin (1 x 10(-15)-1 x 10(-3) mg/ml) respectively. The results showed that opioid peptides can modify NK cell function.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Cells, Cultured
  • Enkephalin, Leucine / pharmacology*
  • Enkephalin, Methionine / pharmacology*
  • Female
  • Killer Cells, Natural / drug effects
  • Killer Cells, Natural / immunology*
  • Male
  • Mice
  • Mice, Inbred BALB C


  • Enkephalin, Methionine
  • Enkephalin, Leucine