Brief report: mediation of treatment effect in a communication intervention for pre-school children with autism

J Autism Dev Disord. 2012 Mar;42(3):447-54. doi: 10.1007/s10803-011-1248-3.


Tests of mediation in treatment trials can illuminate processes of change and suggest causal influences in development. We conducted a mediation analysis of a previously published randomised controlled trial of parent-mediated communication-focused treatment for autism against ordinary care, with 28 children aged 2-5 years (Aldred et al. in J Child Psychol Psychiatr 45:1-11, 2004). The hypothesised mediating process, targeted by the intervention, was an increase in parental synchronous response within parent-child interaction. The results showed partial mediation, with change in synchrony accounting for 34% of the positive intervention effect on autism symptomatology (Autism Diagnostic Observation Schedule communication and social domain algorithm); the result was confirmed by bootstrap estimation. Improved parental synchronous response to child communication can alter short-term autism symptom outcome with targeted therapy.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Autistic Disorder / psychology
  • Autistic Disorder / therapy*
  • Child, Preschool
  • Communication*
  • Family Therapy*
  • Female
  • Humans
  • Male
  • Parent-Child Relations*
  • Treatment Outcome